Key Takeaways
- An ampoule filler sealer machine streamlines filling and sealing in a single coordinated process for efficient production.
- Lodha International LLP is a leading Automatic Ampoule Filling and Sealing Machine Manufacturer in India, offering customized solutions.
- The LI-AFS range accommodates various ampoule sizes and provides filling accuracy of ±1%.
- Key features include nitrogen flushing, slant-travel systems, and PLC-HMI automation for precise control.
- Ampoule filling and sealing machines support diverse applications, including pharmaceuticals, cosmetics, and veterinary formulations.
Glass ampoule filling requires controlled liquid dosing, careful ampoule handling and reliable sealing within a coordinated production process.
At Lodha International LLP, we manufacture ampoule filling and sealing solutions for pharmaceutical, biotech, cosmetic, veterinary and chemical applications. As an Ampoule Filler Sealer Machine Manufacturer in India, we offer multiple LI-AFS configurations to suit different ampoule sizes and production requirements.
What Is an Ampoule Filler Sealer Machine?
An ampoule filler sealer machine combines liquid filling and glass-ampoule sealing within one machine.
Lodha’s LI-AFS range works on the slant-travel principle, which helps accommodate normal variations in ampoule neck dimensions, wall thickness and ovality during filling and sealing. The machine carries out ampoule feeding, neck centering, gas flushing, liquid filling, heating and final sealing in sequence.
This makes the system suitable for manufacturers that need controlled filling and sealing within a continuous ampoule-packaging operation.
How Does an Ampoule Filler Sealer Machine Work?
The operating sequence typically includes:
- Ampoule Feeding: Ampoules are loaded through the in-feed hopper and transferred using a synchronized star wheel.
- Ampoule Positioning: Ampoules move into the transport rack and are centered for the required process stages.
- Pre-Gassing: Nitrogen flushing can be provided before filling where required.
- Liquid Filling: The required volume is dispensed into each ampoule.
- Post-Gassing: Additional nitrogen flushing can be used depending on the product requirement.
- Pre-Heating: The ampoule neck is heated before final sealing.
- Final Sealing: The ampoule neck is flame sealed using the required gas arrangement.
- Tip Removal & Collection: Burned-off ampoule tips are removed by clippers and discharged into a separate container, while filled and sealed ampoules move to collection.
LI-AFS Ampoule Filling & Sealing Models
Lodha offers different head configurations according to ampoule size and required output.
Model | Filling Heads | Ampoule Range | Listed Output |
LI-AFS 1 | Single | 1–20 ml | 15–30 ampoules/min |
LI-AFS 2 | Two | 1–20 ml | 30–55 ampoules/min |
LI-AFS 4 | Four | 1–10 ml | 55–100 ampoules/min |
LI-AFS 6 | Six | 1–10 ml | 80–150 ampoules/min |
LI-AFS 8 | Eight | 1–10 ml | Up to 200 ampoules/min |
The listed filling accuracy is ±1%, while actual performance depends on the product, ampoule format and operating configuration.
As an Automatic Ampoule Filling and Sealing Machine Manufacturer in India, we recommend selecting the configuration according to ampoule size, fill quantity and realistic production requirements rather than output alone.
Automation and Filling-Control Features
Depending on the selected ampoule machine configuration, relevant operating and automation features can include:
- No Ampoule–No Fill functionality
- Ampoule-neck cantering during filling and gas flushing
- Pre- and post-nitrogen flushing
- Pre-warming station
- Controlled ampoule movement
- Adjustable production speed
- Easy changeover for different ampoule sizes
- Accessible design for cleaning and maintenance
- Automatic filled-ampoule collection
For servo-based ampoule filling and sealing configurations, Lodha also offers PLC and HMI control for automatic fill-volume adjustment. Servo-driven filling provides more precise control of the filling process and allows operating parameters to be adjusted through the control interface.
Pharmaceutical Automation & 21 CFR Part 11
For pharmaceutical projects requiring higher levels of electronic control and documentation, applicable PLC-based ampoule filling configurations can be supplied with optional 21 CFR Part 11 software compliance for the HMI/PLC. Qualification documentation such as IQ/OQ/PQ can also be considered according to the approved project scope.
Suitable pharmaceutical machine configurations can be designed to support EU GMP and US FDA cGMP requirements, depending on the machine, automation package and final scope of supply.
IPC with SCADA System should be specified only where it is confirmed for the selected ampoule-machine configuration; it should not be assumed as a standard feature across the full LI-AFS range.
Hygienic Design and Machine Construction
For pharmaceutical ampoule filling, machine materials and cleaning access are important considerations.
Relevant LI-AFS features include:
- SS 316L product-contact parts
- SS 304 non-contact parts
- Stainless-steel machine frame and coverings
- Large lower access area for cleaning and maintenance
- Easy changeover and cleaning
- Minimal maintenance requirement
- Accessible machine components
The LI-AFS specifications identify SS316L for contact parts and SS304 for non-contact parts across the standard filling and sealing configurations.
Key Features for Pharmaceutical Production
When selecting an Ampoule Filler Sealer Machine Manufacturer in India, manufacturers should consider features that directly affect their process:
- No Ampoule–No Fill: Helps avoid dispensing when an ampoule is absent.
- Nitrogen Flushing: Pre- and post-filling flushing is available for applications that require it.
- Slant-Travel System: Supports reliable handling where standard glass ampoules have slight dimensional variations.
- Minimum Changeover: Suitable configurations can handle different ampoule sizes with limited change parts.
- Pre-Warming: Helps prepare the ampoule neck for the sealing process.
- PLC-HMI Automation: Available on applicable servo-based configurations for controlled filling adjustments.
Applications of Ampoule Filler Sealer Machines
Ampoule filling and sealing machines are used for products that require measured filling into sealed glass ampoules.
Applications include:
- Pharmaceutical liquid formulations
- Injectable-product packaging
- Vaccine and biopharmaceutical applications
- Cosmetic serums and ampoule-based products
- Veterinary formulations
- Selected chemical liquids
- Ayurvedic and herbal ampoule applications
Lodha’s current ampoule range includes standard, high-speed, closed-ampoule, servo PLC-based, single-head, four-head and other specialized filling and sealing systems.
Why Choose Lodha International LLP?
we focus on matching the ampoule machine with the actual product, container and production process.
Our range covers single-head through high-speed multi-head ampoule filling and sealing configurations, along with servo PLC-based systems for projects requiring additional automation.
As an Automatic Ampoule Filling and Sealing Machine Manufacturer in India, we provide standard as well as customized configurations based on ampoule size, filling requirement, production output and application needs.
Conclusion
An ampoule filler sealer machine brings filling and sealing together within one coordinated process. Selecting the correct machine requires consideration of ampoule size, filling range, production output, gas flushing, automation and pharmaceutical compliance requirements.
With multiple LI-AFS configurations and servo PLC-based options available, Lodha International LLP can support different pharmaceutical, biotech, cosmetic and related ampoule-packaging requirements.
If you are looking for an Ampoule Filler Sealer Machine Manufacturer in India, contact Lodha International LLP to discuss your ampoule size, fill volume, production requirement and automation needs.
Phone: +91 74350 31331
Email: info@lodhapharma.com Lodha Pharma
Frequently Asked Questions
What is an ampoule filler sealer machine?
An ampoule filler sealer machine combines both liquid filling and sealing of glass ampoules within one automated process. It handles ampoule feeding, gas flushing, liquid filling, and final sealing in a synchronized manner, ensuring precise and efficient production.
How does the automatic ampoule filling and sealing machine work?
The automatic ampoule filling and sealing machine operates in several stages: ampoule feeding, positioning, gas flushing, liquid filling, pre-heating, and final sealing. These steps ensure controlled filling and reliable sealing, accommodating variations in ampoule dimensions.
What are the features of Lodha's ampoule filler sealer machines?
Lodha’s ampoule filler sealer machines feature no ampoule-no fill functionality, pre- and post-nitrogen flushing, and easy changeover for different ampoule sizes. Additionally, they include accessible designs for cleaning and maintenance, as well as options for PLC and HMI control for automated production.
Who should consider using an automatic ampoule filling and sealing machine?
Pharmaceutical, biotech, cosmetic, veterinary, and chemical manufacturers looking for efficient, reliable filling and sealing solutions should consider using an automatic ampoule filling and sealing machine. These machines are particularly essential for products requiring precise dosage in sealed glass ampoules.
Why choose Lodha International LLP as an ampoule filler sealer machine manufacturer in India?
Choosing Lodha International LLP as your ampoule filler sealer machine manufacturer ensures you get customized solutions tailored to your specific needs. Their extensive range of configurations caters to various ampoule sizes, filling requirements, and production outputs, backed by a focus on quality and automation.
